铁死亡在鼻咽癌发生发展及治疗中的研究进展

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中图分类号：R739.6 文献标志码：A 文章编号： 1000-5013（2025）04-0361-08

Research Progress of Ferroptosis in Pathogenesis and Therapy of Nasopharyngeal Carcinoma

WANG Fucai，ZHOU Zhihan，MA Lihao （School ofMedicine，Huaqiao University，Quanzhou 362o21，China）

Abstract：By reviewing the relevant literature in recent years，the concept，characteristics and research pro gress of ferroptosis in the treatment of nasopharyngeal carcinoma were reviewed. The results showed that the mechanism of ferroptosis was complex and it played a key role in the treatment of nasopharyngeal carcinoma. Although the long-term survival rate of nasopharyngeal carcinoma patients had significantly increased，distant metastasis and resistance to radiotherapy and chemotherapy remained the treatment diffculties for nasopharyngeal carcinoma patients. As a novel mode of celldeath characterized by elevated levels of reactive oxygen species and lipid peroxides，ferroptosis was expected to become a new target for clinical intervention in nasopharyngeal carcinoma.

Keywords：nasopharyngeal carcinoma； ferroptosis；mechanism；antibiotics resistance

铁死亡（ferroptosis）是一种以铁依赖性脂质活性氧堆积为特征的细胞死亡，不同于细胞凋亡、细胞坏死和细胞自噬现象，是一种新型的死亡方式[1-2]。（剩余17442字）