基于数字微流控芯片的多通路水相 ¹⁸F 标记工艺

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文章编号：1003-9015（2025）03-0441-07

中图分类号： TL92+3 文献标志码：A DOI：10.3969/j.issn.1003-9015.2025.03.007

Abstract： A small volume multi-channel 18F -labeling process based on digital microfluidic chip technology was developed. 18 F-labeled radioactive compounds were synthesized by this process. Method A digital microfluidic chip（Electroweting-on-dielectric）made of indium tin oxide glassand Teflon material by laser etching magnetron sputtering technology was used to synthesize 18 F labeled radiopharmaceuticals through multiple channels. The most suitablesynthesis conditionwas selectedbylabelingrateandradiochemical yield.The microfluidicchiphasa film volume of1O×10cm，a height of1.1 mm，six synthetic channels，anda heating range from room temperature to 80 C .The synthesis of multiple channels with diffrent precursor concentrations and diffrent reaction times is realized. The radiochemical conversion rate of the synthesized 18 Flabeled radioactive compound is 96.8%，and the radiochemical purityof the product is greater than 99%.The results demonstrate that compared to traditional radiochemical synthesis methods，EWOD allows for the simultaneous synthesis of radiochemicals in diferent systems， significantly reducing the time required tooptimize synthesis conditions andachieving higher conversion yields.This technology accelerates the transition of new radiocompounds into practical applications. Key words：digital microfluidic chip；radiopharmaceutical；fluorine-18； aqueous labeling

1前言

正电子发射型计算机断层扫描（PET）是核医学分子影像技术最具代表性的影像技术[1]，而PET显像剂是实现影像的重要物质，通过放射性合成标记相对应的核素后，经过注射等方式进入实验动物体内，并且可以特异性结合目标靶点，在体内高表达的靶点进行汇聚。（剩余8553字）