力致发光材料的发光机理及生物医学应用研究进展

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Recent AdvancesofLuminescenceMechanismsand Biomedical Applications ofMechanoluminescent Materials

YANG Miao†，GAO Yalin†，LONG Xi，YANG Fan* （SchoolofScience，SunYat-senUniversity，Shenzhen5181O7，China） *CorrespondingAuthor，E-mail：yangf375@mail.sysu.edu.cn

Abstract：Since the discovery of mechanoluminescence，it has undergone decades of development and has been widely applied invarious fields，including sensing，anti-counterfeiting，and structural detection.However，the applicationofmechanoluminescentmaterialsinbiomedicalfieldsisstillinitsearlystages，withrelativelyfewreports available.This paper first introduces advanced strategies for synthesizing mechanoluminescent materials andsystematically discusses several typical mechanoluminescence mechanisms，witha focus on trap-controled mechanoluminescence.Additionaly，it presents therecentlydeveloped novel mechanoluminescencemodels basedonchemiluminescence and bioluminescence.Furthermore，this paper provides a comprehensive overview of theapplications of mechanoluminescent materialsinbiomedical fields，including biosensing，near-infrared bioimaging，optogenetic neuromodulation，and disease treatment.Lastly，this paper summarizes the majorchallngesfaced by mechanoluminescent materials in biomedical applications and proposes their future research directions.

Keywords：mechanoluminescent materials；nanoparticles；biomedical applications；optogenetics

1引言

力致发光是指固体发光材料在受到各种机械应力（摩擦、按压、拉伸、撞击以及聚焦超声等）刺激作用时，产生光发射的现象。（剩余61081字）