多模态MRI影像组学对脑胶质瘤术后复发与治疗后反应的鉴别诊断

打开文本图片集

Diferential diagnosis for recurrnce and treatment response of glioma based on multimodal MRI radiomics

SHI Litingl，2，WANG Yanqin²，LI Chuanting

ChelooCoegeofMedicine，handongUniversity，Jinan25ool2，China;²DepartmentofMedicalImaging，JiningHospital ofXiyuanHospitalofChinaAcademyofChineseMedicalSciences，Jining2720o，China;DepartmentofMedicalImaging， Shandong Provincial Hospital Afliated to Shandong First Medical University，Jinan 25oo21，China.

[Abstract]Objective：Toinvestigatethediferentialdiagnosticvalueforrecurrenceandtreatmentresponseofgliomabasedon multimodalMRIradiomicsmodels.Methods：Aretrospectiveanalysiswasperformedfor110patientswithglioma，allof whom were examined by 3.O T MRI scans，including T1 FLAIR，TWI，TFLAIR，DWI，T，WI-CE and DCE-MRI. 11O cases had abnormalenhancementonpost-treatmentMRIimages.Accordingtothepathologicaldiagnosisand/ormultipleclinicaland imagingfollw-upexaminations，11Ocasesweredividedintotherecurrncegroup（77cases）andpost-treatmentresponse group（33cases）．And11Ocasesweredividedintothetrainingcohortandvalidationcorhortataratioof7：3.Theimages wereimportedintothe3DSliceropen-sourcesoftware，andthelesionsweremanuallydelineatedandtheVOIs were reconstructed，from which the radiomics features were extracted.The -test，MUSE selector and LASSO algorithm were used toscreenfeatures.The RandomForest（RF）wasusedtoconstruct thediagnosticmodel，andtheROCcurve wasused toevaluatethediagnosticperformanceofthemodel.Results：TheTWI，ADC，TW-CE，Ks，V，iAUC，DCE-MRI+TW-CE modelshad7，5，3，7，5，10，5features，andachievedtheAUCsinthevalidationcohortof0.716，0.759，0.836，0.741， 0.836，0.897，.922.Conclusions：ThemultimodelMRIradiomicsmodelshavegooddiagnosticeficacyindiferentiatingglioma recurrenceandpost-treatmentresponse.Comparedwith thesinglesequence model，thecombined modelhas higheracuracy， specificityand sensitivity.

[Key words] Radiomics;Magnetic resonance imaging;Glioma;Recurrence;Treatment-response

脑胶质瘤是中枢神经系统原发肿瘤中最常见的神经上皮肿瘤，占脑肿瘤的 81%[1] ，经标准疗法治疗的患者预后差，复发率高，高级别脑胶质瘤复发率可达 90%[2-3] 。（剩余7752字）