基于fMRI评估经筋循行路径对功能脑网络拓扑结构重塑效果的影响

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Effectof meridian sinewpathwayontopologicalreorganizationoffunctionalbrainnetworksbasesonfMRIassessment ZHANG Gengbiao’，WU Jinghua23，ZHENGHongyi'， LI Weijia'，CHEN Yian4，WANG Jin4，ZHENG Wenbin’ 'DepartmentofoyeondfliedHspalofcalleofouUesity JinrouTraditionalChineseMedicineResearchIstitute，Beijingo，ChinaShantouJinrouTrditionalChineseMedicine Research Institute，hantou55oo，China;MedicalCollege，hantouUniversity，Shantou5504，ina. [Abstract]Objective：Using BOLDresting-statefMRIandgraphtheorytoanalyzethetopologyoffunctionalbrainnetworks inhealthyvoluntersbeforeandafterreceivingvariousmeridiansinewtreatments，inodertorevealthemechanismofmeridian sinewtreatments’influenceonneuralnetworkmodulation.Methods：Thirty-threehealthyvolunteerswererecruitedand randomlyassignedtotheSanyanggroup（18cases）andthe Sanyingroup（15cases）.Simplereactiontime test，Schulte grid test，cranial MRI3D-TWI，andBOLDdata werecolectedbeforeandaftertreatment.GRETNAsoftwarewasusedtoconstruct functionalbrainnetworksandcalculatetopologicalparametersforwithin-groupandbetween-groupcomparisonsbeforeandafter treatment.Results：Aftertreatment，intheSanyanggroup，thereactivityandatentionweregreatlyenhanced，theglobal eficiency，localeficiencyandclusteringcoficientwerelowered，andthecharacteristicpathlengthwaselevated（ll P< 0.05）.While thenormalized characteristic path length wasreducedinthe Sanyin groupafter treatment（ P<0.05 ）．The Sanyanggroupshowedlowernodallocaleficiencyandnodalclusteringcoeficientinbrainregionsofmultiplecognitively relevant networks（all P<0.05 ），themajority of which were in the right cerebral hemisphere（83.3%，15/18）.Correlation analysis revealed that Schulte grid time （GRT）was positively connected with clustering coefficient（ r=0.338，P=0.005） .Conclusions： Themeridiansinewtreatmenttargetingthe Sanyangmeridiansinewcanoptimizethearrngementofthefunctionalnetwork， whichiturnstrengthensthevolunters’reactivityandattention，anditismorenoticeableintheoptimizationofthenetwork operationmodeandthestrengtheningofreactivity/atentionthantheSanyinmeridiansinew.Theintegrationofresting-state fMRIandgraph theorycanprovideanovelconceptandaproach forearlyquantitativeobservationof theeficacyof meridian sinew treatments of neurological illnesses.

[Keywords]Traditionalchinesemedicine;Meridiansinew therapy;Functional magneticresonanceimaging;Graphtheory;Brain functional network

经筋疗法最早记载于《黄帝内经》，是以十二经脉为纲，结合解剖学基础总结人体肌肉、韧带等生理病理规律的中医外治手段。（剩余9711字）