基于多模态MRI探究血管性认知障碍的脑结构与功能影像学特征
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Explorationof brain structureandfunctioncharacteristics ofvascularcognitiveimpairmentpatients based on multimodal MRI
HU Qiyang，LIU Xinyi，ZHOU Yijie，WANG Shuqing，JIANG Wenxian，TANG Wencheng，LIAO Meirong
Department of Neurology，Guilin Hospital of Traditional Chinese Medicine，Guilin 54lOoo，China.
[Abstract]Objective：Usingmultimodal methodsincludingvoxel-basedmorphometry（VBM）andfMRI，toexploretheimaging characteristicsvascularcognitiveimpairment（VCI）.Methods：Atotalof11OVCIpatientswereassessd.UsingtheMontreal cognitiveasesment（MoCA）scores，56caseswithcognitiveimpairmentwereincludedintheobservationgroupand54without cognitiveimpairmentwereincludedinthecontrolgroup.Thediferencesoftotalintracranialvolume（TIV），graymatter volume（GMV），andfractional amplitudeof low-frequencyfluctuation（fALFF）valuesbetween the twogroupswerecompared. Finaly，theaboveindicesofdferentbrainregionsintheobservationgroupwereextractedfororelationanalysswithMCA score.Results：Therewerenostatisticallysignificantdiferencesin'age，genderoryearsofeducationbetweenthetwo groups （all P>0.05 ）. The TIVwas（ 1339.87±135.24）cm3 in the observation group and （ 1 341.57±134.02）cm3 in the control group，with no statistically significant difference between the two groups（ P>0.05 ）.The GMVwas （518.62±48.85）cm3 in the observation group and （536.84±62.53）cm3 in the control group，with a statistically significant difference between the two groups（ P<0.05 ）.Comparedwith thecontrol group，the observationgroup showed decreased GMVinthe bilateral medial superiorfrontalgyrus，bilateralsuperiorfrontalgyrusandrightanteriorcingulatecortex，andincreasedfALFFvaluesinthe bilateralcalcarine，bilateralsuperiorocipital gyrus，leftmiddleoccipitalgyrusandleftcuneus.Conclusion：MultimodalMRI preliminarilyrevealsthedstictstructuralandfunctionalneuroimagingcharacteristicsofVCIpatients，includingdecreased GMVinthefrontallobesandaberrantspontaneousactivityintheoccipitallobe，maycontributetofurtherexplorationof neuroimaging biomarkers and quantifiable diagnostic indicatorsfor VCI inthe future.
[Keywords]Vasculardementia;Graymater;Montreal Cognitive Scale;Voxel-based morphometry;Magneticresonance imaging
在当前人口老龄化加剧的背景下，血管性认知障碍（vascular cognitiveimpairment，VCI）已成为全社会的沉重负担[1]。（剩余8973字）