内脏脂肪代谢评分纵向变化和累积暴露水平与心血管疾病风险的相关性研究：来自CHARLS队列研究

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Longitudinal Changes and Cumulative Exposure of Metabolic Score for Visceral Fat and Risk of Cardiovascular Disease ： A Study from CHARLS Cohort

ZHAO Min，LI Qi，REN Hongqiang （Department of Cardiovascular Center，Suining Central Hospital，Suining 629ooo，Sichuan，China）

【Abstract】ObjectieToexploreteasoiationbetweenthelongiudinalchangesandcumulatieexposueoftemetabolicsorefor visceralfat（METS-VF）ndincidentcardiovasculardisease（CVD）anditssubtypes（eartdiseaseandstroke）intheChinesepopulation. MethodsDatawereanalyzedfromtheChinaHealthandRetirementLongitudinal Study.FourMETS-VFcategorieswereidentifiedby K-meansclusteranalysisbasedonmeasurementsin2O11and2O15.CumulativeMETS-VFexposurewascalculated.MultivariateCox regressionaalyssaspefodndotetialofoingfactoserecotolledtvaateteocatioetwe-Fdicidet CVD.Restitedcubicsplineanalysisevauatedhedose-responserelationshipbetweencumulativeMES-VFexposureandincidentCVD risk.Subgroupaalysisanduliablecompetingiskmodelsreusedtoassstebustsofteults.ResutsAtotalof481 participants wereincluded，with6incidentCVcasesobservedfrom2015to2020.ComparedtoClss1（lowestMETS-VF）Class （highest METS-VF）was associated with a 111% increased risk of incident CVD（ HR=2 .11，95%CI1.55～2.88），a 77% increased risk of heart disease （ HR=1.77，95%CI 1.22～2.57 ），and a 137% increased risk of stroke（ HR=2.37，95%CI1.50～3.74） .Apositive linear corelatinwasfoundbetweecumulativeMETS-VFexposureandCVDrisk.ConcusionSustainedhiglevelsandexcessvecuulative exposureofMES-VFareassiatedithanincreasdiskoficidentCV.DamicoitoingofMES-VFisucialforCVDpevetion and control.

【KeyWords】Metabolicscoreforvisceralfat;Visceralfat;Cardiovasculardisease;ChinaHealthandRetirementLongitudinal Study

心血管疾病（cardiovasculardisease，CVD）是全球范围内致残致死的主要原因之一，类型包括冠心病、心力衰竭和脑卒中等，其发病机制与行为、环境和代谢异常密切相关[1]。（剩余9708字）