IRX3在心血管疾病中的多面角色：从脂肪褐变到治疗新靶点

Multifaceted Role of IRX3 in Cardiovascular Diseases ： from Adipose Browning to New Therapeutic Targets

HU Xiaoyong1，YANG Yongxin²，ZHANG Yongxing1 ，LI Hongjian'

（1.Departmentof Hypertension，The FifthAfliated Hospitalof Xinjiang Medical University，Urumqi 83o，Xinjiang， China；2.DepartmentofCardiology，TheAfliated HospitalofSouthwest Jiaotong University，he ThirdPeople'sHospital of Chengdu，Chengdu 610031，Sichuan，China）

【Abstract】Iroquois homeobox3（IX3）gneisamemberoftheIroquoishmeoboxfamily.Asoneof tetranscriptionfactors，itplays apivotalroleinmbryonicdvelopmentellarmetabolismndtegulationofriousysiologicalproceses.Emergngvidence indicatesthatIRX3egulatestecovesionofhiteadiposetisuetobrowadiposetisue，promotingadiposebrowingadeibiinga strongcorelionwiesitydcadiovaslardiseas.isviprovidsoncseovevoftoleulariolgicalhacteisti of IRX3，its role in adipose browning and cardiovascular diseases，and its potential as a therapeutic target.

Keywords】Iroquois homeobox 3;Transcription factor;Cardiovascular disease;Adipose browning;Therapeutic targe

心血管疾病是导致人类死亡和疾病负担的主要原因之一，其发病机制复杂，涉及多种遗传和环境因素的相互作用。（剩余12526字）