HFpEF合并CKD患者的联合管理策略

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Combined Management Strategies for Patients with HFpEF and CKD

DENG Yaoting'，LU Weijie²，SHENG Pengcheng³，LIUMengyang1，HU Yujie4，YANG Kang'，OU Xiaopeng'，WANGBowen， XIE Pings

（1.The First Clinical Medical Colegeof Gansu Universityof Traditional Chinese Medicine，Lanzhou 73o03o，Gansu， China;2.Colegeof IntegratedTraditional ChineseandWestern Medicine，Gansu Universityof Traditional Chinese Medicine，Lanzhou 730030，Gansu，China;3.Bengbu Medical University，Bengbu 2330，Anhui，China;4.TheFirst Clinical Medical CollegeofLanzhou University，Lanzhou 730o30，Gansu，China;5.Departmentof Cardiology，Gansu Provincial People’s Hospital，Lanzhou 73OO3O，Gansu，China）

【Abstract）Heartfilure with preserved ejectionfraction（HFpEF）andchronic kidneydisease（CKD）aretwocommonandmutully influencingdseasstatsigificantltpatprgosisloballtprealeofFsocatdiissingdis incidencerateandmortaityaeighertanothertyesofHpEF.Epidemiologicaldatasuggstastrongbdirectioalelatioshibetwen HFpEFadCKDithaighicidenceiachter’spatientpopulatios，eadingtosigniicanticreasesintheicidencefardosular eventsandallaseoralityepathophsiologicalmchanismiolvesngesinasularfunctioniaioofenangiotesin aldosteronesystemchronicimmationadmetabolicdisodersandtesefactorsinteracttofurtheragravatethedamageofartnd kideyfuctiisatsokco greatvalueinatintdentificationdiskstraifiatioIesoftramentgoesineoreprilysinbitodoteo antagonist，soseaspeidllatioveootetialiovindalosie lackofspecifictherapiesAtthesametime，precisionmdicineandcombinationtherapystrategiesareexpectedtofurtheroptimizethe management of patients with HFpEF and CKD.

【Keywords】Heartfailure withpreservedjectionfraction;Chronic kidneydisease;Pathophysiology;Diagnosis;Treatment;Manageent

随着全球人口老龄化的加剧，慢性病的负担持续加重，其中射血分数保留的心力衰竭（heartfailurewithpreservedejectionfraction，HFpEF）与慢性肾脏病（chronickidneydisease，CKD）作为两种常见且相互关联的慢性疾病，其患病率呈现显著上升趋势。（剩余13446字）