线粒体自噬在慢性心力衰竭中的研究进展

打开文本图片集

Mitochondrial Autophagy in Chronic Heart Failure

HE Jian 1，2 ，YUE Tian1，XIONG Shiqiang1，YANG Jiali 2 ，HOU Jun1 （1.Departmentof Cardiology，The Third People's Hospitalof Chengdu，Chengdu 610031，Sichuan，China;2.Schoolof Life Science and Engineering，Southwest Jiaotong University，Chengdu 61o031，Sichuan，China）

【Abstract】Chronicheart failureisaseriouscardiovasculardiseasewithacomplexanddiversepathological process in which mitochondrialautohagyplasakeyole.Mitochondrialautopagyisaspecialisedautopagicprossthatmaintainscellaralthand functionbyselectivelyremovingdamagedordysfunctionalmitochondria.Inheartfailure，mitochondrialautophagymaintainsetabolic homeostasisandfuctioalabilifadoysbygtighodalualityooleuatingodatietrssdosis， whilemitochodrialutoagisioedimodelingthtoodrialoktsuorttedaptiveesposeofardoytsi strefulvttusadtsofaccalitevesdlaioraltoa potentialintereamentofadiovaslardisess.Thisticleviesteasicoceptsndmchanismsofitochondialutog wellas itsroleinchronicheartfailure，providingatheoreticalbasisandnewideas forfutureresearchandclinical treatment.

【Keywords】Chronic heartfilure;Mitochondrialautophagy;Cardiomyocyte;Oxidative stress;Apoptosis;Cardioprotection

慢性心力衰竭（chronicheartfailure，CHF）是一种常见的、严重的心血管疾病，其特征是心脏无法泵出足够的血液以满足身体的需求[1-2]。（剩余14810字）