NEDD4L基因在心血管疾病中的作用研究进展：多态性及其他机制

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Role of NEDD4L Gene in Cardiovascular Diseases : Polymorphism and Other Mechanisms

YANG Di,LIU Danan

(DepartmentofCardiologyheAffliatedHospitalofGuizhouMedical University,InstituteofMedicalSciences,Guizhou

Medical University,Guiyang55ooO4,Guizhou,China)

【Abstract】Cardiovasculardiseases havebecomeasignificantchalengefortheglobalmedicalcommunityduetotheirhighincidence andmortalityts.RentsdiesverevealedattelopsofthNDDLeneisgradualltractigteaetioofa inthefieldofadovaslardiseasseprteiecdedyheDLgeneplasucialoleinologicalprocesssuchselal transductionllaidtosisIslotctioofdoslasei themechanismofDLgene’sinfuenceoncardiovasclardiseass,latedepidemiloicalsudiesndtheirlinicalsignifica.I explorestheposibilitfDsomakerfoadasardiseasadotetialtrapeticargAttetiial thelimitationsfrerseachndfutureachetiosigtrovddeasdbsiforhlagsisdraf cardiovascular diseases.

【Keywords】 NEDD4L gene;Polymorphism; Cardiovascular disease;Epidemiology;Biomarker

心血管疾病（cardiovasculardisease，CVD）是全球主要致死病因，遗传机制在其发病中起关键作用[-2]其中神经前体细胞表达发育调控样蛋白4（neuralprecursor cell expressed developmentally down-regulated4-like，NEDD4L)基因编码的E3泛素连接酶通过调控细胞信号转导（如 -catenin和MAPK通路）、内质网应激及代谢稳态，在心血管病理过程中发挥双重作用[3-5]，其单核苷酸多态性（如 rs4149601 )与南非人群耐药性高血压易感性相关，可能影响抗高血压药的疗效[6-7]；而蛋白表达异常则通过介导心肌细胞凋亡、炎症反应及脂质代谢紊乱，参与心肌肥厚、动脉粥样硬化等病理进程[8-9]。（剩余14453字）