睡眠障碍与关节炎对充血性心力衰竭风险的影响研究

打开文本图片集

【Abstract】ObjectiveToexploretheinfluenceofsleedisorderandarthritisoncongestiveheartfailure（CHF）andprovide referencesforpreventionandinterventionMethodsDataof6648participantsfrom2—2020wereselected.ThosewithCHarthitis， slpdisorderisingdataumors，rpregancyreecuded.Missngvalusofothariablesereandedbyultipleimpatiod 33052wereincludedintheanalysis.The“survey”packageinRsoftwarewasusedforweighteddataanalysis.Amultivariablelogistic regressionmodelwasapliedtoanaletheinteractioetweerisdsleepdisorderonCHFfteradutigforconfoundersuboup analysis was done by gender （male，female）and age （ <40，40～60，>60 ）to further explore the effects on CHF.ResultsArthritis （ OR= 1.437，95% CI1.207～1.710）and sleep disorder（ OR=2.006，95% CI1.582～2.542）were both significantly associated with CHF.The association was stronger when both existed （ OR=2 .558，95% CI 2.092～3.127），but multiplicative and additive interaction effcts were not significant.Subgroup analysis showed similar results in male，female， 40～60 ，and > 60 subgroups as in the total population. Conclusion SleepdisorderandarthritisareindependentlyandsignificantlyasociatedwithCHF.Teircombinedefectshosnosignificantsyergy. Furthereseachontheunderlyingmechanismsandinteractionsamongsleepdisorder，thritis，ndcardiovascularhealthiseded.

【Keywords】 Sleep disorder；Arthritis；Congestive heart failure；Interaction

充血性心力衰竭（congestiveheartfailure，CHF）是全球心血管疾病致死致残的主要原因之一，它因心脏结构或功能异常，使心室充盈或射血能力受损，临床多表现为呼吸困难、乏力、液体潴留等，病理机制复杂，与多种生理和生活因素有关。（剩余8771字）