线粒体自噬在糖尿病心肌病中的研究进展

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Mitophagy in Diabetic Cardiomyopathy

ZHANG Tengxu，LI Ziwei，XU Ying，XU Chaoqun，WANG Hao，Rui Tao （People's Hospital Affiliated to Jiangsu University，Zhenjiang212OO2，Jiangsu，China）

【Abstract】Cardiovasculardisease isamajorcauseofdeath inpeoplewithdabetes.Diabeticcardiomyopathy（DCM）involvesmyocardial hypertrophyadfosisuetodabetesitouterartoditios，eadingtopaiedartfuctioitoagtprocfoig damagedmitocdia，isucialforellhalthdlaskyolei.abeesidativestressdhrfctoscasupto inheartels，ausingmichondrialdfunctionadeakendhartfunctioTeK/Parkinpathwaiseyfoitopagglationa ubiquitin，utitoaltiatinueyocaalageibetesubqtiolingd contributestoDC.TisarticleeploresthepathophsiologofC，etailsitopagymechanisms，vieselatedpathaysndsgsts regulating mitophagy as a potential treatment strategy，providing new clinical insights.

【Keywords】Diabeticcardiomyopathy;Mitophagy;Mitochondrial dysfunction;Oxidative stress;PINK1/Parkin pathway

糖尿病心肌病（diabeticcardiomyopathy，DCM）这一概念最早由Rubler等[1]于1972年提出，其主要特征包括心肌肥厚及间质纤维化最终导致心功能障碍。（剩余12898字）