心力衰竭时红细胞变化及机制探讨

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【Abstract】 The heart，a high oxygen-consuming organ，accounts for merely 0.5% of total body weight yet contributes to over 10.0% of systemicoxygosuptiAseparyiclefoygndlierytoholocaladfuctioaltabilityfrdloell）s criticalformaintainingcardiacomeostasisHeartfilure（HF），theterminalstageofvarouscardiovasculardseases，sfrequently acompanedbysignifcantRBCaerationsimorphologyandfunctionduringdseaseprogresson.Previusstudeshavedmostratedthat redcellvolumedistributionwidthstronglycorelateswithdverseprognosisinpatientswithHFhileRBCabnomalitiesmayfurther exacerbateHFprgessoypaingdoelialdardoytefutioTisvsthesiuentevdencoeriphallo RBCaltratiosiHFndheiruderlingmechanismsimngtoprovideoelinsightsforHFessmentandterapeuticategies.

【Keywords】Heart failure;Red bloodcell;Red cellvolume distribution width;Anemia;Extracellular vesicle

心力衰竭（heartfailure，HF）是一种复杂的临床综合征，是多种心血管疾病（cardiovasculardisease，CVD）的终末状态或严重阶段，其特征是心脏无法有效地泵血满足身体的代谢需求。（剩余11994字）