谷氨酰胺代谢在肺动脉高压中的研究进展

打开文本图片集

【Abstract】Abnoal glutaminemetabolismisonsideredtobeinvolvedintheabnoalproliferationofpumonaryvascularesand themaintenanceoformalcardiacfunctioninpulmonaryhypertension，hichcanprovidenewideasforthetreatmentplanofpulonary hypertension.Tisarticleainlyeviesthbiologicalfunctionsofglutamineinpulmonaryhypertensionthmolecularpathwaioldin thepathogeesisfoartesidiseeoscllfloyeresivdingicalfor the treatment of pulmonary hypertension from the perspective of material metabolism.

【Keywords】 Pulmonary hypertension; Glutamine;Metabolism

肺动脉高压（pulmonaryhypertension，PH）是一种由多因素引起、以平均肺动脉压升高为特征的血流动力学疾病，其病理学特征是小中肺动脉重塑，这种重塑导致的外周血管阻力增加会加重右心室后负荷，持续进展导致右心室肥厚、右心输出量减少、右心衰竭和死亡[2]。（剩余11592字）