IL-1R2在心血管疾病中的研究进展

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Role of IL-1R2 in Cardiovascular Diseases

ZHANG Jiangmei，YU Kunwu，ZENG Qiutang

（DepartmentofCardiology，Union Hospital，Tongji Medical Colege，Huazhong Universityof Scienceand Technology，

Wuhan 430022，Hubei，China）

【Abstract】Cardiovasculardiseasesareoneoftheleadingglobalhealththreats，andinflammationplaysacriticalroleintheir pathogenesis.teleukin（I）isnpantinendiflammatordiatorioedinriouiatoyndispse proceses.IL-epto（-）2s"deecetoanindspeifcallto-ereybockinisteactionihialig receptorL-andfectivelyaleviatingteiflammatoryespose.StudiesavesowntatIL-exetsprotecieectsinvarious pathologicalcoitiosuchstrosleosisyocadialih-epefusioijurydyadalmodelingyiingdel celldamagehuelllolifadoossplof novelterapeutictargetinardiovasculardiseases，eviecentexperimentaldatandcliicalesearch，andhighlightfutureac directionsandchalenges，withthegoalof providingnew insightsintothepreventionand treatmentofcardiovasculardiseases.

【Keywords】Interleukin-1receptortype2;Inflammation;Cardiovascular disease;Pathogenesis;Prevention and treatment

心血管疾病（cardiovasculardisease，CVD）是全球主要致死原因之一，每年造成约1800万人死亡，占全球死亡总数的 30%[1] 。（剩余14053字）