基于UHPLC-QE-MS技术识别稳定型心绞痛 患者血清代谢组学特征

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【DOI10.16806/j.cnki.issn.1004-3934.2025.07.018

Identification of Serum Metabolomics Characteristics in Patients with Stable Angina Pectoris Using UHPLC-QE-MS

JIANG Hanmei，RUAN Hongwei，LIU Ping，LIANG Junjie，JIANG Yan，LUO Gang

（Southwest MedicalUniversityDepartmentofCardiovascularedicine，AfliatedrditionalineseMedicineHospital， Southwest Medical University，National Traditional Chinese Medicine Clinical Research Base，Luzhou 646o，Sichuan， China）

【Abstract】ObjectiveStableangina pectoris（SAP）isoneofthemaintypesofcoronaryheart disease.New methods forthe prevention，earlydiagnosisandtreatmentofSAPeededtobeexploredclinicalyandthresearchtoachievethisgoalfocuothe discoveryofnewbomarkers.MethodsInthisstudy，3Opatients withSAP（SAPgroup）and30patientswithoutcoronaryarterystenosis （CON group）wereselected.First，UHPLC-QE-MStechnologywasusedtodetectserummetabolitesinbothgroups，ndthenmultiariate stiticalanalysisandpathayanalysisereusedtoevaatetechangesinserummetabolicprofiles.ResultsOP-Aanalyisidetfed significandiferencesinteserummetabolicprofilesbetweenSAPgoupndCOgroup，nd26diferentialmetabolitesereentified. Pathwayaalyisfoundtattseieretialetablteeoldineretabolismidativerssuieetablidotr metabolicpathways.ConclusionBycomparingtheserummetabolicproflesofSAPgroupndCONgroup，26potentialbiomarkersand 7 metabolic pathways were identified，which can be used to guidethe prevention，early diagnosis and treatmentof SAP.

【Keywords】 Coronary heart disease;Stable angina pectoris;Metabonomics;Clinical study

近年来，中国心血管疾病患者呈逐年增加趋势，其中冠心病（coronaryheart disease，CHD）的患病人数居于心血管疾病第二位，其发病年龄近年来逐渐年轻化，极大地威胁了人类健康，增加了经济负担[1-2]。（剩余14351字）