氧化应激在射血分数保留的心力衰竭中的作用与相关治疗的研究进展

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【DOI]10. 16806/j. cnki. issn.1004-3934.2025.07.007

RoleofOxidativeStressin HeartFailurewith Preserved Ejection Fraction and Related Therapy

YAO Wei，ZHANG Xiao，SUN Hui，LI Jin，TANG Tongdan

（Departmentof WardofEmergencyof Internal Medicine，Central Hospital of Dalian UniversityofTechnology，Dalian 116033，Liaoning，China）

【Abstract】Theincidencerate，rehospitalizationrate，admortalityofeartfailurewithpreseredjectionfraction（HFpEF）continue toncreasewithiceasingeandtedenofhypertesionadetabliciseaseInecentyeasidativtrsshasbensugestete asignificantpathogenicmechanisminHpEF，andprogresshasbeenmadeinunderstandingitsefectsonothcardiacanderacardiac tissues.HoweerHFminsudercogdinliicalpactie.Thisticevithvideneoeoleofdatiessiny pathologicalstepsofFpFindingadocytertoph，gendohodrialdfnctiodmmarsthef drugs to treat oxidative stress in HFpEF.

【 Keywords】 Oxidative stress; Heart failure with preserved ejection fraction;Reactive oxygen species;Antioxidant

心力衰竭（heartfailure，HF）是一个巨大的公共卫生问题，全球患者数超过6400万，且呈逐年上升趋势[1]。（剩余14438字）