miR-199a-3p在冠状动脉粥样硬化性心脏病中的研究进展

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Roleof miR-199a-3p in Coronary Atherosclerotic Heart Disease

HUANG Yunjie， WU Hong （Departmentof Cardiology，Changhai Hospital Afliated to Naval Medical University，Shanghai 2O0433，China）

【Abstract】MicroRNAsareagroupofnon-codingRNAsabout 22nucleotidesthatnegativelyregulategeneexpresionattheposttranscriptionalvel.Amongte，te-99afmilyoselyelatedtoroaytheroleroticartdseaseadplasanporatole inpathologicalschaiadal-fsidoaalsisutef miR-199a-3pinant-athroslerosisadmyocardialproteio，tisveailysummarzedtespcificoleofi-199a-3pintheplaque forationstagyoadalishepefusioijuyagedmyocadalpairsaeofooaryrosleroticeartdisssl theuseofmiR-199a-3p-loadednanoformulationsastherapeuticapproaches，hichwillprovideanewideaforthefuturefundamentaland clinical research.

Keywords】 Coronary atherosclerotic heartdisease;MicroRNA;miR-199a-3p;Nanoformulation

冠状动脉粥样硬化性心脏病（冠心病）在中国的患病率和死亡率逐年上升，2020年，冠心病患者死亡率在中国城市为126.91/10万，农村为135.88/10万[1]。（剩余9370字）