PLIN5通过调节脂肪酸代谢改善肺动脉高压心室功能的作用机制研究
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Mechanism of Action of PLIN5 in Improving Ventricular Function in Pulmonary Arterial Hypertension by Regulating Fatty Acid Metabolism
Danzengdunzhu1，GAO Han1，QIN Shanshan1，XIONG Shiqiang2，YANG Jiali ，HEJian2，YUE Tian ，HOU Jun2 （1.MedicalColege，Tibet University，Lhasa 85000，Tibet，China；2.Department of Cardiology，The ThirdPeople’ s Hospital of Chengdu，Chengdu 610031，Sichuan，China）
【Abstract】ObjectiveToinvestigatetheoleandpotentialinfluenceofperilipin5（PLI5）intheabormalitisoflipidmetabolism inhypoxicpulmonaryhypertensionrats.MethodsTheratmodelsof hypoxicpulmonaryhypertensionwereconstructedbymeansofa hypobaricoxygenchamberandrightventriclarstructureandfunctionandhaemodynamicindexesreasessedinoal/Pkockout miceinanormal/hypoxicenvironmentforevaluatingrightventricularfunction.TheefectsofhypoxiaandPLN5onfatyacidmetabolism wereaessedbysystemiclipidmetabolismcumulationandchangesinlocalfattcidmetabolitelevelsinteartTeectsofyoia andPLIN5ontheexpresionandactivityofkeyenzyesinfattacidmetabolismweresubsequentlyevaluatedtoexploreteotential influenceofPIN5onfattacidmetabolism.Byevaluatingthestructureandfunctionofcardiomyocytemitochondria，weexploredthe protectivefectofI5onmitochondriathoughtheregulationofattyacidmetabolism.ResultsHypoxicpulmonaryhypertesionwas asociatedwithsructuralhangsndfuntioaldifteightveticleichereaggavatedy5eficiecytat acidmetabolisitsderoaloditiosutispathonic.Inatsioicpuoaryhertesiosigcatly fattacidetabasdencdbyeoagfttcidsisdteitatiooffatycidodatiogatcid synthesisndoxidationbymodulatingthactivitiesoffatyacidsynthaseandhormone-sensitivelipase.Meanwhile，LI5canprotect cardiomyocytemitochondriafrommitochondrialdamagecausedbyabnormalfattyacidmetaboismbyregulatingfattacidmetabolis.
ConclusionPLIN5protectshypoxicpulmonaryhypertensioncardiomyocytesfrommitochonrialdamageinducedbyabnomalfatyacid metabolism by regulating fatty acid metabolism of fatty acid synthesis and oxidation.
【Keywords】 Hypoxic pulmonary hypertension；Perilipin 5；Fatty acid metabolism； Mitochondrion
低氧肺动脉高压（hypoxic pulmonaryhypertension，HPH）是长期低氧状态导致的肺动脉压力升高的疾病，HPH高死亡率极大程度上加重了社会和家庭的医疗负担[1-3] 。（剩余10999字）