表观生物年龄加速预测老年重度冠状动脉钙化患者行冠状动脉旋磨术后主要不良心血管事件的研究

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Association Between Epigenetic Age Acceleration and Major Adverse Cardiovascular Events in Elderly Patients with Severe Coronary Artery Calcification After Rotational Atherectomy

LIRuiting，MAYue，MA Rui，ZHANGRongxiu，LIUZhanwen

（Cardiovascular Medicine Department，The Third People’s Hospital of Xinjiang Uygur Autonomous Region，Urumqi

830000， Xinjiang ，China）

【Abstract】ObectiveToinvestigatethrelationshipbetweenepigeneticgeacceleration（EAA）ndtheoccurnceofmajoradverse cardiovascularevents（MACE）afterrotationalatherectomy（RA）inelderlypatientswithseverecoronaryarterycalcification（CAC）.

MethodsAretrospetivestudywasconductedonatotalof2O6elderlypatientswithsevereCACwhounderwentRAatTheThirdPeople's Hospital of Xinjiang Uygur Autonomous Region from July2O13 toAugust 2O23.The patients werecategorized into EAA + group（PhenoAge> actualage）andEAA-group（PhenoAge （204 0.619）.TheAUCvaluesfortheROCcurveat1，3，5，and8yearswereO.72，.76，0.78，andO.75，respectivelyDCAresulslso demonstratedthegoodpredictivevalueofEAAforMACE，whilethecalibrationcurveindicatedahighmodelacuracy.Thenomogram visualized heriskofACEourrenceinpatients.ConclusionThereisarelatioshipbetweenEAAandtheocurenceofMCEafterRA inelderlypatintswithsevereCAC，whichcan helphealthcare providers identify high-riskpatientsandimprovepatientoutcomes.

【Keywords】Epigeneticageaceleration；Coronaryarterycalefication；Elderlypatient；Rotationalatherectomy；Majoradverse cardiovascular events

冠状动脉钙化（coronaryarterycalcification，CAC）是指冠状动脉血管壁内出现钙质沉积的现象，是动脉粥样硬化的一种表现。（剩余7849字）