光蛋白聚糖在钙化性主动脉瓣疾病中的作用机制与潜在治疗靶点的研究进展

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TheMechanisms ofLumican in Calcific Aortic Valve Disease and Its Potential Therapeutic Targets

DUAN Qingsong ，HU Houxiang1 （1.DepartmentofCardology，Afiiated Hospitalof North Sichuan Medical College，Nanchong 637o，Sichuan，China； 2.Department of Cardiology，Guangyuan First People’ s Hospital，Guangyuan 6280oo，Sichuan，China）

【Abstract】Calcificaortic valvedisease（CAVD）isa leadingcauseof aorticvalve stenosis.The progressionof CAVD isclosely associatedwitcalpschstoacetiodelgdltioetlye memberof thesallucinechproteglycafmilyasgaeedignifantatetninCAV.isvieummarzesteprs mechanisms of lumican in CAVD and discusses its potential as a therapeutic target.

Keywords】 Calcific aortic valve disease；Lumican；Extracellular matrix remodeling

钙化性主动脉瓣疾病（calcific aortic valve disease，CAVD）是老年人群中最为常见的瓣膜性心脏病之一，随着全球人口老龄化的加剧，CAVD的患病率呈现出逐年上升的趋势，目前已成为导致老年人主动脉瓣狭窄的主要原因[1]。（剩余11795字）