RNA结合基序蛋白介导的可变剪接在心力衰竭中的作用机制进展

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Mechanism of RNA Binding Motif Protein Mediated Alternative Splicing in Heart Failure

ZHANG Keyi， YANG Ping

（ University， 65oo，Yunnan，）

【Abstract】Alterativesplicing（AS）isapost-transcptionalmechanismthatgeneratesdiverseproteinisoforsfromasiglegene.Its mainfunctionistoremoveintronsandinkexonstoformaturemessngerRNA（mRNA）RNAbindingprotein（RB）areaclassofproeis thatregulatethemetablicprocesofRNAbindingandarecolectivelyeferedtoasproteinstatbindtoRNA.Theyareakeyfactorn regulatingAS.TheyafectthechoiceofsplicingsisbyecogzingspecificsequeneelementsandbindingtoteprecursorA（pre mRNA）.Thisleadstoabomalexpresionordsfunctionofsomedisease-relatedgens.RNAbindingmotifprotein（RBM）areaniportant class of RBP，and they play an important role in heart failure by regulating the AS pattern of cardiomyocytes.

【Keywords】Alternativesplicing；RNAbindingmotifprotein2O；RNAbindingmotif protein24；RNAbindingmotifprotein25 Heart failure

心力衰竭（heartfailure，HF），是一种心脏泵血功能受损的病理状态，其特征是心输出量不足以满足全身组织的基本代谢需求，这种状态可由多种原因引起。（剩余12556字）