肿瘤坏死因子相关凋亡诱导配体在心力衰竭中的研究进展

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Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand in Heart Failure

LIU Rui1，LIU Yongming2

（1.The First Clinical MedicalCoegeofLanzhou UniversityLanzhou 730o3o，Gansu，China；2.Geriatric Cardiovascular Department，TheFirstHospitalof Lanzhou UniversityGansuProvincial ClinicalResearch Centerfor GeriatricDiseases， Lanzhou ，Gansu，China）

【Abstract】Heartfailure，aglobal publichealthconcern，hasacomplexandmultifariouscause.Atpresent，therearefewclinical treatmentsavalable.Themorcosisfctorsupefamil’stumorrosisfctor-elatedapoptosis-nducinglgand（TAIL）sdraw extensiveateioirthrafoisilteleiveldueotosisiellsoghptcntRetsus havedemonstratedtatotolyeetstorctstllaporntlogicalolsinrocesslatedtoartfure， includingmyocardalcelldeathandcadiacremodeling.TisevidelvesintotesignaligpathwaymediatedyRAILtemchasmsf itsactionnthoccureneanddevelopmentofhartfure，andexplorestepotentialvalueofAILanditseeptosinthclinical diagnosis and treatment of heart failure，providing new treatments for heart failure patients.

【Keywords】 Heart failure；Tumor necrosis factor-related apoptosis-inducing ligand；Apoptosis

心力衰竭（heartfailure，HF）是一种由于心脏的泵血能力下降引起肺循环和/或体循环出现淤血、器官/组织的血液供应减少，无法满足机体新陈代谢需要的临床综合征[1]。（剩余10968字）