线粒体质量控制在阿霉素诱导的心脏毒性中的研究进展

打开文本图片集

Mitochondrial Quality Control in Doxorubicin Cardiotoxicity

WANG Xinyu1，WANG Yuqi1，LUO Haowen1，CHANG Pan ，ZHAO Xiaohong1 （1.DepartmentofAnesthesia，Second Clinical Medical Colege，Xi’an Medical University，Xi’an7O38，Shaanxi，hina； 2. Department of Basic Medical Sciences，Air Force Medical University，Xi’ an 71Oo36，Shaanxi，China）

【Abstract】Doxorubicinisabroad-spectrumantitumordrugwithcleareficacyagainstavarietyofmalignancies，butsevere cardiotoxicityliislcalplicatioprspeoftug.iocodaualityoroltaischdalomeosasislate mitochondrialfunction，andparticipatesimyocadialijuryandepairtoughmitohondrialbogensis，itohondrialaic mitophagySeveaudieshvesotatiochodrialaltyontrolplasaniporatoleinteardiotoxicfectsofdoxobicinut theunderlyingmolecuarmechanismsstllrequirefurtherivestigation.Tisartcleeviesteoleandmechansmofmitochondialuality controlindoxobicinadiotoxicitdsovedinentyars.Iucidateolefitchdialualityotrolindooicin cardiotoxitypovideirectionfoprevetionfdoxorubicin-relatedadotoicidtodentifotetialtapeticaetsfor cardiotoxicity.

【Keywords】 Doxorubicin；Mitochondrial quality control；Cardiotoxicity

阿霉素（doxorubicin，DOX）作为一种疗效明确的蒽环类药物，被广泛应用于各种恶性肿瘤的治疗，如乳腺癌、白血病、霍奇金淋巴瘤等[1]，但1/4的患者出现累积性和剂量依赖性心脏毒性，使该药物的临床应用受到极大限制[2]。（剩余10928字）