微生物生源要素循环过程与抗生素抗性基因增殖传播的耦联机制研究进展

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关键词：抗生素抗性基因；生源要素；生物化学循环；代谢途径；影响机制中图分类号：X172 文献标志码：A 文章编号：1672-2043（2025）06-1422-17 doi：10.11654/jaes.2024-0680

Review on the coupled mechanisms of microbial biogenic element cycles and the proliferation and dissemination of antibiotic resistance genes

XU Yi1，2 ，FU Tinghong1，²，YANG Shihong²，SU Xinke²，ZHANG Zeyang²，YOU Guoxiang'，HOU Jun1

（1.KeyLaboratoryofIntegratedRegulationandResourcesDevelopmentonShallowLakesofMinistryofEducation，Colegeof Environment，HhaiUniversityNanjingo98，China;2.CollgfAgriculturalSienendEngineering，HohaiUniversityjing ， China）

Abstract：Asanovelboogicalpolutant，antiboticesistanegnes（ARGs）poseasignificant threattoumanhalthbyspreadingand diseminatinginteenvironmentviamicrobialvectors.Thecyclingofbiogenicelementsisafundmentalprocess thatsustaisicrobal physiologicalandmetabolicactii，ingucialolinmedatingteproiferatoddissmatioofitracellarGsed ontheexistingresearchfindings，thispapersystematicallyreviewstergulatoryfectsofmicrobialintracellarmetabolicpathways， intermediates，ndkyproesesfrbon，rogenospous，ndooobialommuityuctureadARGsprolatio diseminationThecoupledmechanismsbetweemicrobialbiogenicelementcylesandtheproliferationanddissminationofARsare explored，aimigtoroideaeticalfoudtiondietificsisfoudatingeteactielatioipteeicoal metabolic activities and ARG spread，deepening the research connotation of ARGs environmental behavior.

Keywords：antibioticresistancegenes;biogenicelements;biochemicalcycles;metabolicpathway;influence mechanisms

目前抗生素抗性问题已成为全球性的公共卫生挑战[-2]。（剩余47475字）