高通量微流控平台在肿瘤精准诊疗中的应用研究进展

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[中图分类号] R730.5 [文献标志码] A

Advances in the application of high-throughput microfluidic platforms in precise diagnosis and treat

ment of tumorsDOU Liliang，CHU Jiahui，LIU Lian（Department of Medical Oncology， Qilu Hospital of Shandong University，Jinan 250012，China）

[ABSTRACT]Although thetreatmentof malignant tumors has enteredaneraofcomprehensivetherapy integrating chemo therapy，targetedtherapymmunotherap，andthermodalities，thereisstillasignificantgapfroindividualedprecisetreat ment.Thedevelopmentofinuiuoandinuitrodrugsensitivitytesting models haspromotedtheadvances infunctional precision medicine.Among these models，high-troughputmicrofluidicplatformsoferdistinctadvantagesforinitrodrugsensitivitytesting duetotheirfeaturesofhighthroughput，ighsensitivityighintegration，andminiaturization，therebyenablingprecisemanipulationof microlitervolumefluidflowandreactionsandsimulatingtheliquid microenvironmentof tumorgrowthThisarticlereviews therecentresearchadvancesintheaplicationofhigh-throughputmicrofluidicplatformsintheprecisediagnosisandtreatmentof tumors，in order to provide a reference for the individualized treatment of malignant tumors.

[KEYWORDs]High-throughput screening assays；Drug screening assays，antitumor; Tumor microenvironment；Precision medicine；Editorial

刘联，山东大学齐鲁医学院肿瘤学系副主任，齐鲁医院肿瘤学教研室副主任，山东省恶性肿瘤精准诊疗重点实验室副主任；齐鲁医院肿瘤内科主任、主任医师、教授、博士研究生导师。（剩余17830字）