转录因子PU.1在炎症性疾病中的研究进展

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【中图分类号】R392【文献标志码】A

Research advances in the transcription factor purine rich box-1 in inflammatorydiseases

YuanYiting'，TianAi²

（1.School of Stomatology，Guizhou Medical University;2.Department of Prosthodontics and Implantology TheAffliated Stomatological Hospital ofGuizhou Medical University）

【AbstractInflammatorydseasesareagroupofdisorderscausdbyaboralactivationofteimmunesystem，includingutoimune diseases，chronciflammatoryboweldisaseetaboliciammatoryisassndprodonitisetransctionfctorineic box-1（PU.1）playsanimportantroleinthedevelopmentandprogressionofinflammatorydiseasesbyregulatingthedevelopmetand diferentiationofimmunecellandrelatedinflammatorysignalingpathways.Inrecentyears，studieshave graduallyrevealedthecentralroleofPU.iniflamatorysposeandghghteditsliicalaplcationvaluesapotetialtrapeticget.isarticl systematicallsummarestebiologicalfaturesandgulatoryehanismsofU.explorsitsoleiniflmmatorysposead commoniflammatorydiseses，ndalzesitslinicalapplicationrategies，dertoproideeferenceforfuturesachnd clinical application.

【Key words】purine rich box-1;SPI1 gene;inflammatory diseases;immune regulation;therapeutic target

炎症性疾病（inflammatorydiseases，ID）被定义为由环境、遗传和病原体感染等多种因素综合作用引起的复杂疾病。（剩余19071字）