氯马斯汀调控少突胶质细胞髓鞘修复的机制研究进展

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【中图分类号】R741

【文献标志码】A

Research advances in the mechanism of clemastine regulating oligodendrocytesand remyelination

Zhang Xiaojuan'，Chen Yao²，Zhang Chao²，Tang Binbin²，Chen Xianjun² （1.Department of Pharmacy，Sichuan Second Hospital of Traditional Chinese Medicine;2.Departmentof Physiology， School of Basic Medical Sciences，Chongqing Medical University）

【AbstractOligodendrocytes（OLs）playacrucialroleinthecentralnervoussystem，andthe myelinsheath formedbythemissetial formaintaining thenormalfunctionofthenervoussystem.Damagetothemyelinsheathcantriggrvariousnervoussystemdiseases， whichseriouslyectthequalityoflifeofpatints.Clemasti，traditioalatiistamine，assowncerainpotentialin“repposing olddrugs”inrecentyearsandcanpromotetherepairofmyelinsheath.Thisarticlesummarizestheroleofclemastineinregulatingthe diferentiationaturationesencendapoptosisfOLsatultiplelvelsbyctingoreceptosonthOLmembraneadglat ingthekesignalingpathwaysincellandepgeneticmodificationsinteucleus.Adeeperunderstandingoftemechanismofaction of clemastineinOLscan help toprovidenewtargetsandnew approachesfordrug treatmentof myelin-degenerativediseases.

【Keywords】clemastine;oligodendrocyte;myelin sheath repair;nervous system diseases

少突胶质细胞（oligodendrocyte，OL）谱系是中枢神经系统（centralnervoussystem，CNS）中最主要的胶质细胞类型之一，由少突胶质前体细胞（oligodendrocyteprecursorcell，OPC）发育分化而来。（剩余17035字）