心房颤动患者左心耳血栓形成机制的研究进展

中图分类号：R541.7 文献标志码：A DOI：10.11958/20251816

Abstract：Atrial fibrillation （AF） isone themostcommonclinical arrhythmiasandasignificant risk factor for thromboembolism.Theleft atrial appendage（LAA）isthe primarysite thrombus formation inAFpatients.Recentstudies haveexplored themechanisms LAA thrombosis frommultiple dimensions，includinganatomical structure （LAA morphologyandarchitecture），functional indicators （hemodynamicalterations），pathophysiological mechanisms（endothelial injury，inflammatoryactivation），ystemiciseases （renaldyfunction）andgeneticfactors （genepolymorpisms），proviing critical evidenceforpreciseclinicalanticoagulation.Thisarticlesystematicallreviews thelatestresearchadvances inthe mechanisms LAA thrombosis in AF patients，aiming to er theoretical support forthe accurate assessment thromboembolicriskandtheformulationindividualizedanticoagulationstrategies.Additionalyitlaysthefoundationfor exploring theintrinsicrelationshipandmechanismsbetween LAAhemodynamicsandheart failureaswellas thromboembolic events.

Keywords：atrial fibrillation;atrial appendage; thrombosis

心房颤动（房颤）是临床上最常见的房性心律失常之一，其特征为快速、无序的心房电生理活动[1]。（剩余11709字）