心外膜脂肪厚度联合血清ADAM10、STIM1对冠心病的诊断价值
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中图分类号：R542.2 文献标志码：A DOI：10.11958/20250781
Abstract：ObjectiveTo explore the diagnosticvalue of epicardial adipose tissue （EAT）thickness combined with serum disintegrin metaloprotease 1O（ADAM10）and stromal interaction molecule1（STM1） incoronary heart disease （CHD）. MethodsA total of 119 CHD patients were included as the study group，and 10O non-CHD patients in the same period wereselectedasthecontrol group.Theclinical dataof the patients werecollcted.SerumADAM10andSTIM1levels were detected by enzyme-linked immunosorbent assay （ELISA）.Color Doppler ultrasonography was applied todetectEAT thickness.Multivariate Logisticregression wasused toanalyze influencing factors of CHDoccurrence.The diagnostic value of EATthicknesscombined with serum ADAM10and STIM1levels in the diagnosis ofCHD wasanalyzedbysubject work characteristics （ROC）curves.ResultsThe levelsof triglycerides，low-density lipoproteincholesterol （LDL-C），EAT thickness，serum ADAM1O and STIM1 were higher in the study group than those in the control group （ P<0.05 ）. Logistic regression analysisshowed that elevatedEAT thickness，serum ADAM10，STIM1，triglycerideand LDL-C levels were independent risk factors for the occurrence of CHD（ P<0.05 ）.ROC curve analysis showed that the area under the curve of EAT thickness combined with serum ADAM10 and STIM1 for the diagnosis of CHD [0.864（95%CI： 0.811-0.907）] was higherthanthatof theirrespectiveindividual diagnoses[0.801（95%CI：0.741-0.851），0.750（95%CI： 0.687-0.806）， respectively，0.799（95%CI： 0.740-0.850）]，and thesensitivityandspecificityof thecombineddiagnosis were 82.35% and 83.00% ，respectively. ConclusionEAT thickness，serum ADAM1O and STIM1 levels are obviously elevated in CHD patients，and the combination of the three tests has a high diagnostic value for CHD.
Key words：coronary disease；epicardial adipose tissue thickness；adisintegrinand metalloprotease1O;stromal interaction molecule 1
冠心病（CHD）是临床上较为常见的心血管疾病，在全球范围内具有较高的患病率和死亡率，已成为人类主要死亡原因之一，其发病年龄呈年轻化趋势，给社会和家庭带来了严重影响[1]。（剩余10062字）
