哌拉西林他唑巴坦致低钾血症的危险因素分析

打开文本图片集

中图分类号：R978.11，R591.11 文献标志码：A DOI：10.11958/20252000

Abstract：ObjectiveToanalyze risk factorsofhypokalemiaafter treatment with piperacillin-tazobactam（PTZ）and to provide areference forsafe clinical medication.MethodsAretrospectivecollction of 1355 inpatients treated with PTZ was conducted.Patients were assigned to the hypokalemia group （serum potassium <3.5 mmol/L，374 cases） and the nonhypokalemia group （serum potassium ⩾3.5 mmol/L，981 cases） based on whether they suffered from hypokalemia after PTZ treatment.Clinicaldata werecolectedandcompared inbothgroupsofpatients.MultifactorialLogisticregressionanalysis wasusedtoidentifytheinfluencingfactorsof hypokalemiainducedbyPTZ.ResultsInthehypokalemia group，there were 308 cases of mild hypokalemia （82.3% ），63 cases of moderate hypokalemia and 3 cases of severe hypokalemia.The incidence ofmoderate to severe hypokalemia was 4.9% ，with the lowest serum potassium concentration recorded at 2.1 mmol/L.The proportionof females，treatment duration，cumulative dosage，age-adjusted Charlson Comorbidity Index（aCCI），the percentage of patients with platelets （PLT） < 100×10°/L and the proportion of patients using glucocorticoids were all higher in thehypokalemia group than those of the non-hypokalemia group（ P<0.05 ）. Conversely，baseline serum potassium levels and red blood cell （RBC） were lower in the hypokalemia group than those of the non-hypokalemia group （ P<0.05 ）.Multivariate Logisticregresionanalysis indicated that female，increased cumulative dosage，elevatedaCCIand lower baselineserum potassium concentration were risk factors for PTZ induced hypokalemia （ P<0.05 ）.ConclusionFemale，lower basline serum potassiumlevel，long-termhigh-doseuseofPTZandhighcomorbidityindexareriskfactorsfortheoccurrenceof PTZ-induced hypokalemia.Thechanges inserum potassium during the medication period of this type of patients shouldbe closely monitored to ensure the safety of drug use for patients.

Key words：hypokalemia;piperacilin，tazobactam drug combination;drug-related side effectsandadversereactions; risk factors; femininity;age-adjusted Charlson comorbidity index

低钾血症是一种常见的电解质异常。（剩余12007字）