阻塞性睡眠呼吸暂停和心房颤动因果关系的多组学孟德尔随机化分析

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中图分类号：R563.9 文献标志码：A D0I：10.11958/20250987

Abstract： ObjectiveTo analysethe causal relationship betweenobstructive slep apnea （OSA） atrial fibrillation （AF）byMendelianromization（MR）method， toexploretheroleinflammatoryfactors，immunecels，blood metabolitescirculating proteins init.MethodsInthisstudy，MRanalysiswasused toinvestigatethecausal link between OSAAF.Inversevariance weighting（IVW），MR-Egger other methodswereusedforsensitivityanalysis. Additionally，thesdyalsoexploredtheffcts91inflammatoryfactors，71immunecels，40Obloodmetaboits 4 907 circulating proteins on AF.ResultsMR analysis revealed a significant causal relationship between OSA AF 0 OR=1.078 ）.Conversely，reverse MR analysisdid not find causal relationship between AF OSA P>0.05 ）Furtheranalysis revealedthat5inflammatoryfactors，19immunecels，15bloodmetabolites67circulating proteins were riskfactorsforAF.Amongthem，OSAwastheriskfactorforoneinflammatoryfactor，one bloodmetabolite12circulating proteins.Therewas no significant causal association between OSA 19 immune cels.ConclusionThis study demonstrates thatOSAincreases theriskAF.Meanwhile，itisfoundthatinflammatoryfactors，immunecels，blood metabolites circulating proteins have potential impacts on the pathogenesis AF.

Keywords：sleepapnea，obstructive；atrial fibrillation; Mendelianromizationanalysis；inflammatory factors; immune cells; metabolites; plasma proteins

阻塞性睡眠呼吸暂停（obstructive sleep apnea，OSA）是由于复发性完全性（呼吸暂停）和部分性（低通气）上气道阻塞而导致间歇性低氧血症、自主神经波动和睡眠碎片化。（剩余10755字）