原发性肝癌患者术前免疫因素及与病理特征的关系

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中图分类号：R735.7 文献标志码：A DOI：10.11958/20251548

Abstract：ObjectiveTo analyzechanges of preoperative Tlymphocyte immunityand humoral immunity，and their relationshipwithpathologicalcharacteristicsinpatients with primary hepatocelularcarcinoma （HCC）.MethodsAtotalof 150patients with primary HCCunderwent elective surgical treatment wereenrolldas the HCC group，while15O healthy controls during thesame period wereenrolledas thecontrol group.Before surgery，the levels of peripheral blood CD 3+ ，CD4+ and CD8 + were detected byflowcytometry，and CD4+/CD8+was calculated.The levels of IgA，IgGand IgM inperipheral bloodwere detectedbyimmunoturbidimetry.Thepathological characteristicsof HCC patientswerecolected，and the diferencesof preoperative immune indexes inpatientswith diferentpathological characteristicswere compared.The receiveroperating curve（ROC）wasusedto evaluate thepredictivevalue of immune indicatorsfor pathological characteristics.ResultsThe levels of CD 3+ ，CD4 and CD4+/CD8 + were lower in the HCC group than those in the control group，while levels of CD 8+ ，IgA，IgG and IgM were higher in the HCC group than those in the control group （ P<0.05 ）. The levels of CD3 3+ ，CD4+and CD4+/CD8+were lower in patients with lymph node metastasis than those of patients with distant lymph non-metastasis P<0.05 ）. The levels of CD8+， IgA ，IgG and IgM were higher in patients with lymph node metastasis than those of patients without metastasis （ ）. The results of receiver operating characteristic （ROC） curves showed that area under the curve （AUC） values of CD3+， CD4+ CD8+ ，CD4+/CD8+， IgA ，IgG，and IgM for predicting lymph node metastasis in HCC patientswere0.810，0.741，0.770，0.707，0.756，0.738and0.727.ConclusionThere areabnormalchangesof preoperativeTlymphocyteimmunityandhumoral immunityinpatients with primaryHCC，whicharecloselyrelatedto lymph node metastasis.

KeyWords：carcinoma，hepatocelular;immunity，cellular;immunityhumoral;preoperative;pathologicalchracterisl

目前原发性肝细胞癌（hepatocellular carcinoma，HCC）常采用手术治疗，但由于HCC发病隐匿，早期症状不明显，且缺乏可靠的筛查方法，大部分患者确诊时已为晚期，使其无法行手术根治，导致预后较差[1]。（剩余9760字）