获得性免疫缺陷综合征合并隐球菌脑膜炎45例患者临床特点分析

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【Abstract】 Objective The clinical characteristics of AIDS patients with cryptococcal meningitis CM were analyzed.MethodsA retrospective analysis was conducted to colect clinical characteristics，laboratory findings and outcome data of AIDS patients with CM from thePulmonary Hospital afiliated to Shanxi Medical University fromJanuary 2018 to January 2O23.ResultsA total of 45cases of AIDS combined with CMwere included.The age range of the patients was 38.0（32.0，51.5）years，witha median CD4+Tlymphocyte count of 58 （38，107）cells 'μl The overall mortality rate was 26.7% （12/45）.Among the 45 patients，16 were in the poor prognosis group（death or transfer to higher-levelhospital），withamediansurvival timeof9.5days，while29weredischargednormally.The analysis results showed that thepor prognosis group had significantly higher levels of mental abnormalities， consciousnessdisorders，increased intracranial pressure，and lactatedehydrogenase levels incerebrospinal fluid compared to the normal discharge group（all P<0.05 ）. ConclusionAIDS patients with CMhave a high mortality rate， underscoring theneed to strengthen education and cryptococcal screening for high-risk groups to facilitate early diagnosis and intervention，thereby reducing the case fatality rate.

【Key words】 Acquired immunodeficiency syndrome; Cryptococcal meningitis； Clinical featuresDOI：10.19522/j.cnki.1671-5098.2025.09.015

隐球菌性脑膜炎（cryptococcalmeningitis，CM）是一种由隐球菌属引发，侵袭中枢神经系统的传染性疾病，同时也是获得性免疫缺陷综合征（acquired immunodeficiency syn-drome，AIDS）患者中主要的机会性感染之一[2。（剩余8087字）