肾周脂肪与肾癌患者预后及病理分级的相关性研究

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【Abstract】 Objective To investigate the correlation between perirenal fat area （PFA）and the prognosis and pathological grade of patients with renal cell carcinoma （RCC）.MethodsThe clinical and imaging data of 150 patients with RCC admitted to Shanxi Bethune Hospital from January 2O18 to January 2O25 were retrospectively analyzed，andtheywere divided intogood prognosis groupandadvancedrecurrence groupaccording to the follow-up results，and the pathological gradeof 126 cases of clearcellrenalcellcarcinoma（ccRCC）was recorded.The visceral fatarea（VFA） wascalculated，and the degreeof perirenal fataggregation （PFA% ），PFA%=PFA/（SFA + VFA）x100%. The diferences between the clinical dataand the above measurement indicators were analyzed，andthecorrelation of each factor in the pathological grade was determined bylogisticregression analysis.ResultsThe PFA and PFA% of the prognosis group were lower than those of the advanced recurrence group （ P=0.003 ），but there was no significant diffrence between the SFA and VFA groups （P>O.05）.In the pathological grading model of ccRCC， the PFA% of patients in the high-grade group was higher （ P =0.019）and the maximum diameter of tumors was larger（ P=0.006 ）.Therewasno significant differenceinPFA，SFAand VFA between the two（ P>0.05） ，and PFA% was closely related to the pathological grade of clear cell renal cell carcinoma ⌊OR（95%CI）=1.113（1.008 1.230），P=O.O34].ConclusionPerirenalfatrange is a potential index for predicting the degreeof malignancyand prognosis of RCC patients.

【Keywords】 Carcinoma，renal cell;Perirenal fat;ObesityDOI：10.19522/j.cnki.1671-5098.2025.09.009

肾细胞癌（renalcellcarcinoma，RCC）是肾脏最常见的恶性肿瘤，约占肾脏恶性肿瘤的 90%[1] ，其中透明细胞（肾细胞）癌（clearcellrenalcellcarcinoma，ccRCC）是最常见的亚型，约占RCC的 70% 由于其生物学行为的高度异质性及病理分型的多样性，导致其在临床上的预后差异显著。（剩余7421字）