IRF3通过IFN-I依赖与非依赖途径双向调控细菌感染的研究进展

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关键词：干扰素调节因子3；细菌感染；干扰素

中图分类号：R392 文献标志码：A 文章编号：2097-7174（2026）02-0163-08

DOI：10.3969/j.issn.2097-7174.2026.02.010

Research progress on bidirectional regulation of bacterial infection by IRF3 through IFN- I -dependent and independent pathways

XIE Xiaoyan，PENG Yanting，CHEN Xiaoming，LIU Zhiping （KeyLaboratoryof Innate Immunityand Chronic InflammatoryDiseases，DepartmentofEducationofJiangxi，Gannan Medical University，Ganzhou，Jiangxi ）

Abstract：Interferonregulatoryfactor3（IRF3）isakeymemberoftheinterferonregulatoryfactors（IRFs）family.Itisa crucial transcriptionfactor inregulating host-bacteriainteractions，anditsactivationisessentialfortypeIinterferon （IFN-I）-mediatedantibacterialdefense.However，thefunctionofIRF3inbacterialinfectionsisnotstatic：changesin thecellarmicroenvironmentor diferences in activated signaling pathwayscan transform it froma "defender"toa "promoter".ThisarticlereviewsthemechanismofIRF3asamultifunctionaltranscriptionfactorinbacterial infections， withafocusonrecentresearchprogress inits involvementindiferentbacterialinfectionprocesses throughinducing IFN-I expression or IFN-I-independent signal transductionpathways，with theaimof providing a theoretical basis for the clinical treatment of bacterial infections.

KeyWords：Interferon regulatory factor3；Bacterial infections；Interferon

干扰素调节因子3（Interferonregulatory factor3，IRF3）作为干扰素调节因子（Interferonregulatoryfactors，IRFs）家族的核心成员，在调控宿主免疫应答中发挥关键作用。（剩余13690字）