无创心肌做功技术在乳腺癌患者双靶向治疗相关心脏毒性早期评估中的研究进展

中图分类号：R445.1 文献标志码：A 文章编号：2097-7174（2026）02-0130-08

DOI：10.3969/j. issn.2097-7174.2026.02.005

The research progress of non-invasive myocardial work technology in early assessment of cardiotoxicity associated with dual-target therapy in breastcancerpatients

CHENGJuan，XIELi 1 ，CHENWeihua² （1.The First Clinical Medical School of Gannan Medical University；2.Department of Ultrasound， The First Affiliated Hospital of Gannan Medical University，Ganzhou，Jiangxi 341000）

Abstract：Withthewidespreadapplicationofhuman epidermalgrowth factorreceptor2（HER2）targeteddualtherapyin breastcancer treatment，related cardiotoxicityisuesare increasingly becominga pressing challenge tobeadressed clinically.Non-invasive myocardial work（MW）technology，an emerging evaluation toobasedonechocardiographic pressure-strainloops，showspotential intheearlydiagnosisofcardiotoxicityinbreastcancer patients.Thisarticle systematicallreviews the potential mechanismsofcardiotoxicityrelated to HER2-targeted dual therapyin breastcancer andthelimitations of existing diagnosticandtreatment methods.Thetheoretical basis，measurementmethods，and core parametersofnon-invasivemyocardial work technologyare discussed in depth.Based onthe latest literature，this articleanalyzesthesensitivityandspecificityadvantagesofnon-invasivemyocardialwork technologyintheearly identificationofcardiotoxicity，comparing itwith traditionalassssment markers.Additionally，thepreliminaryclinical aplicationresultsofthis technologyindynamicallymonitoring changesinheartfunctionandguiding individualized treatmentadjustmentsaresummarized.Current studies indicate thatnon-invasive myocardialwork technologyoutperforms traditionalmethodsintheearlydetectionofcardiotoxicityrelatedtoHER2-targeteddualtherapyinbreastcancer，with higher sensitivityandbroader prospects.However，mostcurrentstudiesaresmal-scale，single-centerexploratorystudies， andhigher-levelclinicalevidenceisneededforvalidation.Futureresearchshouldfocusonmulti-center，large-scale， prospectiveclinical trials，standardizing measurement processs，andactivelyexploringAI-assistedanalysisandmultimodal imaging integration，withthegoalof incorporatingthis technologyintotheclinicaldecision-makingpathwayof cardio-oncologyand related guidelines.

Keywords：Breast cancer；Dual-targeted therapy；Cardiotoxicity；Non-invasive myocardial work

乳腺癌目前已成为全球女性中最常见的恶性肿瘤，也是中国女性癌症相关死亡的主要原因之一。（剩余17698字）