富血小板血浆联合中医外治法治疗膝骨关节炎的研究进展

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中图分类号：R684.3 文献标志码：A 文章编号：2097-7174（2026）02-0156-07

DOI：10.3969/j.issn.2097-7174.2026.02.009

Research advances in the treatment of knee osteoarthritis with platelet-rich plasma combined with external therapies of Traditional Chinese Medicine

GUO Mingcui1，XIAO Rui，JIN Jiani¹，ZHANG Mingjin² （1.Schoolof Rehabilitation，Gannan Medical University；2.The ThirdAfliated HospitalofGannan Medical University， Ganzhou，Jiangxi ）

Abstract：Knee osteoarthritis（KOA）isachronicdiseasecharacterizedbythedegenerationof articularcartilage，and its clinical management faces challngessuch as poorcartilage regeneration.Platelet-rich plasma（PRP），rich in various growthfactors，exhibitspotential inpromotingcartilagerepair，inhibiting inflammation，andmodulatingbonemetabolism. External therapiesof Traditional Chinese Medicine，basedonthetheoryof "liver-kidneydeficiencyandqi stagnationand blood stasis"，employmethods suchas herbal patches，fumigation，andacupuncture todispel wind-cold，promote blood circulation，andremove meridian obstruction.Thecombinationof both approachescanallviate inflammation through multi-targetsynergisticefects：PRPpromoteschondrocyteproliferationandmatrixsynthesiswhileupregulatingantiinflammatoryfactors；Traditional Chinese Medicine external therapies enhancePRPactivitybyimprovinglocalcirculation and regulatingqi-blood balance.Clinical studies haveshownthat combined therapies，suchasPRPwith warm needle acupuncture，acupotomy，orherbalfumigation，cansignificantlyreducelevelsofinflammatoryandpainmediatorsopared with single treatments，with goodsafetyprofiles.Currentresearch stillhas limitations，including smallsamplesizes，lack of standardization inPRPpreparation，and incompleteelucidationofsynergistic mechansms.Future efortsshouldfocus onconductinglarge-sampleclinical studies，standardizingPRPpreparationprotocols，clarifying thesynergistic mechanisms oftraditional Chineseand Westernmedicine，and exploringcombination therapies withstemcelsorpersonalizedtreatment strategies to improve the precision and eficacy of KOA management.

Keywords：Knee osteoarthritis；Platelet-richplasma；ExternaltherapiesofTraditionalChinese Medicine；Acupuncture therapy;Acupotomy

膝骨关节炎（Kneeosteoarthritis，KOA）是一种常见且累及关节及其周围组织的慢性疾病，主要是膝关节软骨进行性损伤和伴随的骨质增生，进而导致软骨下骨、韧带、周围的滑膜和肌肉损伤。（剩余16335字）