帕金森病患者DBS术后切口愈合不良影响因素探究及列线图的构建

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【中图分类号】 R742.5 【文献标志码】A 【文章编号】 1672-7770（2026）01-0036-07

Influencing factors and development of nomogram for poor incision healing after deep brain stimulation in patients with Parkinson's disease WANG Lijuan， ZHU Ping， LIANG Qian，WANG Xin，WANG Jing. Department of Neurosurgery， Tangdu Hospital，Air Force Medical University， Xi'an 710038， China

Corresponding author： WANG Jing

Abstract： Objective To analyze the influencing factors for poor incision healing after deep brain stimulation（DBS） in patients with Parkinson’s disease（PD） and to construct a nomogram for facilitating theclinical screening of high-risk individuals.MethodsA total of 575 PD patients who underwent DBS surgery in the Department of Neurosurgery，Tangdu Hospital，Air Force Medical University from January1st，2018 to December 31st，2O22 were included.Patients were followed for 6 months postoperatively and divided into two groups based on incision healing outcomes，the good healing group（ n=535 ） and the poor healing group（ n=40 ）. The clinical data were retrospectively compared between the two groups.Multivariate Logistic regresson was used to identify factors influencing poor incision healing. A nomogram model was constructed based on these factors. The discriminativeability，calibration，and clinical utilityofthe model were evaluated using the receiver operating characteristic（ROC） curve，calibration curve，and decision curve analysis（DCA） curve. ResultsAmong the 575 patients，4O cases developed poor incision healing，with an incidence of 7.0% .Multivariate analysis showed that gender， intraoperative blood loss，diabetes，depression score，and preoperative albumin were independent influencing factors，The area under the curve （AUC） for the nomogram was 0.920（ 95%CI=0.881--0.960 ）.ConclusionsThe risk of poor incision healing after DBS surgery in PD patients can be effectively predicted using factors including gender， intraoperative blood loss，diabetes，depression score，and preoperative albumin． The nomogram serves as a valuable tool for early identification of high-risk patients and guidance of clinical intervention.

Key Words： Parkinson's disease；postoperative poor incision healing； risk factor； nomogram

流行病学调查显示，截至2021年，中国帕金森病（Parkinson'sdisease，PD）发病率和患病率分别为每10万人口24.3例和245.7例，远高于全球平均水平[1]。（剩余13831字）