嗜粘蛋白阿克曼氏菌与心血管及代谢性疾病相关性的研究进展

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Abstract： Cardiovasculardisease （CVD）isoneof the leadingcausesof death globaly，characterizedbyhighmorbidityand mortalityrates.MetabolicdisordersarecriticalriskfactorsforCVD.Inrecentyears，growingevidencehashighlightedthe crucialroleofguticrobiotaintheoset，progesionandpathologicalmechanismsofbothmetabolicdiseasesand. Akkermansiamuciiphila（A.mucinipila），apromisingnxtgenerationprobiotic，hasatractedconsiderableateniondueto its unique metabolic functions and immunomodulatory properties.This review systematically summarizes the mechanisms andresearchprogressregardingtheroleofA.muciniphilainmetabolicdiseasesandcardiovasculardiseases.Itelucidateshow thisbacteriumexertsbeneficialefectsonmetabolicdisordersthroughmultiplepathways，ncludingimprovinggutbarrier function，eglaglipddoemebsmasgtinattciddiopingo responses.MeanwhileA.muciniphilaisalsonvolvedincardiovasularprotectieprocessessuchasanti-atherosclerosisblod pressureregulation，allviationofatrialfibilltion，andimprovementofpulmonaryarterial hypertension.Itsmechanisms involveimmunomodulation，regulationofmetabolites，andmuli-evelinteractionsalongthegutcardiovascularaisoing novelmicrobial targetsandstrategiesforinterveninginrelateddiseases.

Keywords： Akkermansia muciniphila; gutMicrobiota; metabolicdisease;cardiovasculardiseases

心血管疾病（CVD）是全球范围内导致死亡的主要疾病之一，其发生因素复杂多变，既受到基因因素的影响，也与环境因素密切相关。（剩余15432字）