针刺对动脉粥样硬化小鼠血脂和炎性因子的影响研究

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[中图分类号］R245 [文献标志码］A [文章编号]0256-7415（2026）07-0143-05

DOl：10.13457/j.cnki.jncm.2026.07.022

Study on Effects of Acupuncture on Blood Lipids and Inflammatory Factors in Mice with Atherosclerosis

LIN Sisi，QIN Yiyan，QIN Ziqin，FENG Ling，TANG Weiwei，WU Xuefen Guizhou Universityof Traditional Chinese Medicine，Guiyang Guizhou 55OO25，China

Abstract：Objective：To investigate the effects of acupuncture on blood lipid levels and inflammatory factors in mice with atherosclerosis （AS）.Methods：A total of 10 male C57BL/6Jmice were asigned as the blank control group， and another 30 male ApoE -I- mice were randomly divided into the model group，acupuncture group，and shamacupuncture group.The blank control group was fedastandard diet with no intervention；the model group was given a high-fat dietand subjected to 3O minutes of restraint every day.On the basis of themodel group's regimen，the acupuncture group received daily acupuncture as intervention，and the sham-acupuncture group was treated with daily shamacupunctureusing blunt-tip needles.All groups were intervenedcontinuouslyfor12 weeks.Enzyme-linked immunosorbent assay（ELISA）was used to detect the serum levels of apolipoprotein-A（apo-A），apolipoproteinB（apo-B），total cholesterol（TC），triglycerides （TG），vascular celladhesion molecule-1（VCAM-1），tumor necrosis factor- α （TNF -α ），interleukin-1O（IL-1O），and adiponectin in each group of mice after intervention.

Results： Compared with the blank control group，the model group had decreased serum apo-A，IL-10 and adiponectin levels （ P<0.05 ） and increased apo-B，TG，TC，VCAM-1，and TNF- α levels （ P<0.05 ）. Compared with the model group，the acupuncture group showed elevated serum level of apo-A，IL-1O，and adiponectin（ P< 0.05）and reduced apo-B，TG，TC，VCAM-1，and TNF- α levels（ P<0.05 ）. In comparison with the shamacupuncture group，the acupuncture group had higher serum level of apo-A，IL-1O，and adiponectin （ P<0.05 ）and lower TG，TC，and TNF- α levels （ P<0.05 ）. Conclusion： Acupuncture can delay the AS progression by regulating lipid metabolismand inhibiting inflammatoryresponses，and its mechanism maybeassociated with theimprovementof lipid metabolism and the regulation of inflammatory factor expression.

Keywords：Atherosclerosis；Acupuncture；Blood lipids；Inflammatory factors；Mice

动脉粥样硬化（AS）作为一种慢性疾病，可累及全身血脉。（剩余9156字）