胶质瘤基因分型及病理分级与舌象特征相关性研究

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[关键词］胶质瘤；病理；基因分型；舌象特征；相关性分析

[中图分类号］R739.41 [文献标志码］A [文章编号]0256-7415（2026）07-0096-07

DOl：10.13457/j.cnki.jncm.2026.07.016

Study on Correlation Between Genotype and Pathological Grade of Glioma and Tongue Manifestation Characteristics

WU Xiaoyi’，GU Yuyan²，SU Chengmin 1 ，ZHANG Mai1，XIAO Xiang1，HUANGKailin'，WUYuankui'，JIAYuhua²

1.DepartentofImagingDiagnosis，NanfangHospital，SouthernMedicalUniversityGuangzhouGuangdong510515，China；.chool of Traditional Chinese Medicine，Southern Medical University，Guangzhou Guangdong51O515，China

Abstract：Objective：To investigate the correlation between the genotype and pathological grade of glioma and patients'tongue manifestation characteristics.Methods：Aretrospective analysis was conducted on the pathological diagnosis dataof78 patients with glioma.Tongue manifestation images collcted during multiple follow-up visits after surgery and concurrent chemoradiotherapy were reviewed.Tongue manifestation assessment was performed by two Chinese medicine practitioners，covering tongue body color，tongue body size，tongue body shape，tongue coating color，and tongue coating thickness.The correlationbetween tongue manifestation characteristics and diferent genotype subtypes and pathological grades was analyzed.Results：No significant correlation was found between the pathological grade of glioma and the five tongue manifestation characteristics.There was a significant correlation between IDH mutation，1p19q codeletion，MGMT methylation and tongue body shape and size.No significant correlation was observed between IDH mutation，1p19q codeletion，MGMT methylation and tongue body color or tongue coating color. The IDH mutation and lp19q codeletion showed a significantcorrelation with tongue coating thickness，whereas MGMT methylation showed no significant correlation with tongue coating thickness.Conclusion：The IDH mutation，lp19q codeletion，and MGMT methylation ingliomaare correlated with certain tongue manifestation characteristics， suggesting that tongue manifestation may hold potential value in assessng the condition of glioma.

Keywords：Glioma；Pathology；Genotyping；Tongue manifestation characteristics；Correlation analysis

脑胶质瘤是最常见的原发性恶性脑肿瘤。（剩余8220字）