去泛素化酶OTUB2与肿瘤发生发展关系的研究进展

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[中图分类号] R262 [文献标志码] A

ABSTRACTDeubiquitinating enzymes are important hydrolases in the protein ubiquitin system，which regulate the dynamic balance of protein ubiquitination and deubiquitination by reversing ubiquitination，and play important roles in biological processes such as regulating protein stability，cellsignal transduction，and cell apoptosis.As a member of the deubiquitinating enzyme family，ovarian tumor domain-containing protease（OTU） domain ubiquitin aldehyde binding 2（OTUB2） can play a key role in DNA damage， signal transduction，cell metabolism，and tumorigenesis byregulating the ubiquitination levels of various substrates. OTUB2 can be abnormally expressed in various cancers，and as a regulatory factor，it significantly afects the growth，development，proliferation，migration，and invasion ofcancer cels，and is closely related to the prognosis of the patients，potentially becoming a novel cancer therapeutic target and prognostic biomarker. Currently，there are many studies on the molecular mechanisms of OTUB2，but there are few review reports focusing on its role in cancer.Based on the research results about OTUB2 at home and abroad，this article reviewed the biological function of OTUB2，related signaling pathways，and its latest progress in cancer research，analyzed the application of OTUB2 in cancer treatment and prognosis evaluation，and provided new ideas for future research on OTUB2.

KEYWORDsDeubiquitinating enzyme； OTUB2； Signal transduction； Tumor； Signal pathway

泛素化是一种重要的蛋白翻译后修饰，由泛素激活酶E1、泛素结合酶E2和泛素连接酶E3依次进行有序级联。（剩余17521字）