华蟾素调控结直肠癌肿瘤微环境的研究进展

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Research Progress of Cinobufagin in Regulating Tumor Microenvironment of Colorectal Cancer/ LIU Xinchen， ZHANG Zixuan， ZHOU Yajuan， LIU Xiaodong， YIN Maoxu， SUN Leiyu， YANG Lijuan. // Medical Innovation of China， 2025， 22（10）： 175-178

[Abstract]Colorectal cancer （CRC） is one of the most common malignant tumors in the digestive system. Its occurrence and development notonly dependon tumor parenchyma，but also is closelyrelated to itssurvival environment， the tumor microenvironment （TME）. With the deepening of anti-tumor research targeting TME， more and more studies have found that the treatmenttargeting TME has significant advantages，and Cinobufotalin can achieve anti-tumor effect by influencing TME.This article mainly reviews theeffects of common components of tumor associated macrophages （TAMs） and T cells in CRC TME and Cinobufotalin on CRC TME.

[Key words] Colorectal cancer Cinobufagin Tumor microenvironment

First-author's address： Department of Gastroenterology， Affiliated Hospital of Binzhou Medical Jniversity， Binzhou 256600， China

doi：10.3969/j.issn.1674-4985.2025.10.041

结直肠癌（colorectalcancer，CRC）是全球第三大常见恶性肿瘤，也是全球癌症患者死亡的第二大原因，在世界范围内，每年大约有180万新增CRC病例和90万CRC死亡病例。（剩余6674字）