可乐定透皮贴片联合硫必利治疗儿童抽动障碍的疗效分析

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Therapeutic Effect of Clonidine Transdermal Patches Combined with Tiapride in the Treatment of Tic Disorders in Children/LIAO Wenjuan， LUO Juanjuan， ZHU Huifang， CHEN Hengwei， ZENG Wenhui， GUO Bangming.//Medical Innovation of China， 2025， 22（10）： 010-013

[Abstract]Objective：To explore the effcacy of Clonidine Transdermal Patches combined with Tiapride in thetreatmentofchildren withticdisorder.Method：Atotalof106childrenwith ticdisorder admittedtothe First AffliatedHospitalof GannanMedical Universityfrom January 2023toJanuary 2024 were selectedanddivided into two groups with 53 cases in each group according to random number table method.Thecontrol group was treated with Clonidine Transdermal Patches and the observation group was treated with Clonidine Transdermal Patches combined with Tiapride.Theclinicaleffcacy，drug onset time， disease control time and adverse reactions were compared between thetwo groups.The severityof ticdisorder was also assessed before treatment andafter 2，4，6， and8 weeks of treatment.Result： Compared with the control group，the drug onsettime inthe observation group was earlier， the disease control time was shorter， and the total effective rate was higher （ P <0.05）.After 2， 4，6 and 8 weeks of treatmenttheseverityscoresofticdisorder intheobservation groupwerelowerthanthose inthecontrol group （ P <0.05）.There was no significant difference in the incidence of adverse reactions between the two groups ）.Conclusion： Thetreatment of tic disorders in children with ClonidineTransdermal Patches combined with Tiapridehas significant efficacy， which can reduce the severity oftic disorders， alleviate symptoms，and promote

基金项目：赣州市科技计划项目（20222ZDX8578）

赣南医科大学第一附属医院儿科江西赣州341000 赣南医科大学第一附属医院神经外科江西赣州 341000通信作者：郭邦明

physical recovery， and the safety of single treatment and combination therapy is comparable.

[Key words] Clonidine Transdermal Patches Tiapride Tic disorde]

First-author's address： Department of Pediatrics， the First Affiliated Hospital of Gannan Medical University， Ganzhou 341000， China

doi：10.3969/j.issn.1674-4985.2025.10.003

儿童抽动障碍通常是指以突发、重复、不自主抽动为特征的一种精神障碍性疾病，常见于儿童-2]。（剩余5991字）