高危型HPV阳性子宫颈鳞状上皮内病变的影响因素探究

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中图分类号：R711.32 文献标志码：A DOI：10.3969/j.issn.1003-1383.2025.11.010

【Abstract】ObjectiveToexplore the influencing factors of high-risk humanpapiloma virus（HPV）positive cervical squamous intraepithelial lesion（SIL）.MethodsAtotalof742high-risk HPVpositivepatientsadmittedtoMaternaland Child Health Hospitalof Guangxi Zhuang AutonomousRegion from April2O2O to April2O24 wereincluded in thestudy. Aordingto histopathological results，thepatientsweredivided intoSIL group（323cases）andbenigncervical tisue change group（419cases）．Andthen，theclinical dataandvaginalmicroecological indicators werecomparedbetween the twogroups，andmultivariateanalysiswasused toscreen theinfluencing factors forSIdevelopmentinhigh-risk HPV positive patients.ResultsUnivariateand multivariateanalysis revealedthat premenopausalstatus，having more thanone sexual partner，positive P16 expression，positive Ki-67 expression，vaginal cleanliness grade II or IV ，elevated white-blood-cell count，elevated C-reactive protein level，high vaginal pH ，lowLactobacillus level，and young age at first sexual intercourse were risk factors for SIL in high-risk HPV positive patients （ P<0.05 ）. Conclusion There are many risk factors affcting SIL in high-risk HPV positive patient，which can provide reference for early prevention and treatment.

【Keywords】cervical squamous intraepithelial lesion（SI）；humanpapiloma virus （HPV）；isk factors；vaginal microecology

宫颈癌是临床中较为常见的女性恶性肿瘤之一，而子宫颈鳞状上皮内病变（cervical squamous in-traepitheliallesion，SIL）是宫颈癌进展的一个中间阶段。（剩余5959字）