UXS1在肝细胞癌中的表达及临床意义

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中图分类号：R735.7 文献标志码：A DOI：10.3969/j.issn.1003-1383.2025.11.004

【Abstract】ObjectiveTo investigatetheabnormal expressonandclinical significanceofUDP-glucuronatedecarboxylase 1（UXS1）inhepatocelularcarcinoma（HCC）.MethodsBioinformaticsanalysis was employed to preliminarilyexplore the potential functional mechanismsof UXS1in HCCandits prognosticvalue，and expresion diferencesbetween HCC tissues andadjacent tisses were verified through real-time fluorescence quantitative PCR（qPCR）experiments.ResultsAnalysis of the TCGA-LIHC database found that UXS1 was significantlyupregulated in HCC.Multivariate Coxregression analysis showed that UXS1wasan independentrisk factor，while GSVAanalysissuggested that UXS1 mightparticipateintumor progresion byregulating the PI3K-Akt-mTOR signaling pathway，andsignificantly enrichedsmall molecule metabolism， aminoacidmetabolism，andsignalreleaseinbiological processes.TheROCcurveconfirmed thediagnosticeficacyof UXS1 in distinguishing cancer from adjacent cancer （ AUC=0.96 ），and the column chart constructed based on UXS1 and clinical featuresofamultifactorial Cox model predictedthesurvivalriskat1，2，and3 years（C-index=O.6），which wasvalidated through calibration and decisioncurves.QPCR experiments showed that UXS1 was significantly upregulated in HCC（ P=

0.011）.ConclusionThis study is thefirst toreveal that UXS1maypromote HCC progressionthrough ametabolism-signaling pathwaysynergymechanism.Itprovidesatheoretical basis forUXS1asa prognosticbiomarkerandtherapeutictarget， and ofers new directions for exploring novel therapeutic strategies for HCC.

【Keywords】 hepatocellular carcinoma（HCC）；UDP-Glucuronate decarboxylase 1（UXS1）；bioinformatics

肝细胞癌（hepatocellular carcinoma，HCC）是一种极具威胁的消化道恶性肿瘤，已成为全球癌症相关死亡的第三大原因，占原发性肝癌病例的 75% ～80%[1] 。（剩余8946字）