以有氧运动为核心的综合运动对造血干细胞移植病人疲乏的干预效果：Meta分析

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Abstract Objective：To explore the effect of comprehensive exercise with aerobic exercise as the core on alleviating fatigue in patients undergoing hematopoietic stem cell transplantation（HSCT） and its applicable indications.Methods：Randomized controlled trials （RCTs） of the effects of comprehensive exercise with aerobic exercise as the core on fatigue in HSCT patients at home and abroad was retrieved from PubMed，Web of Science，the Cochrane Library，JBI，CNKI，CBM，VIP，and WanFang Database.The retrieval time was from the inception to May 31，2022.Two evaluators independently selected the literature according to the inclusion criteria，extracted the data，and used RevMan 5.3 software for Meta-analysis.Results：Seven RCTs were included，including 413 HSCT patients.Meta-analysis results showed that compared with the control group，aerobic exercise improved fatigue in HSCT patients ［SMD=-0.22，95%CI（-0.42，-0.03），P=0.03］.Subgroup analysis showed that aerobic exercise was performed before transplantation ［SMD=-0.30，95%CI（-0.59，-0.02），P=0.04］，and the duration of intervention was > for 3 months ［SMD=-0.45，95%CI（-0.73，-0.18），P=0.001］.There was statistically significant difference in fatigue between the two groups.Conclusion：Current evidence shows that comprehensive exercise with aerobic exercise as the core can comprehensively improve the functions of multiple organs，such as heart，lung，liver and kidney，promote the rehabilitation of the disease，and then relieve the fatigue symptoms of HSCT patients.It is recommended to start the exercise before the transplantation and the duration should be longer than 3 months.

Keywords blood system;tumor;hematopoietic stem cell transplantation;fatigue;aerobic exercise;Meta-analysis;subgroup analysis

基金项目 湖南省创新型省份建设专项基金项目，编号：2019SK2141

作者简介 刘欢，护师，硕士研究生

*通讯作者 黄辉，E-mail：852152847@qq.com

引用信息 刘欢，李成媛，黄辉，等.以有氧运动为核心的综合运动对造血干细胞移植病人疲乏的干预效果：Meta分析［J］.循证护理，2023，9（8）：1331-1336.

摘要 目的：探讨从有氧运动为核心的综合运动对减轻造血干细胞移植（HSCT）病人疲乏的作用及其适用指征。（剩余9786字）