傣药“雅解沙把”对金色葡萄球菌诱导大鼠乳腺炎的作用机制研究

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【中图分类号】R285.6 【文献标志码】A 【文章编号】1007－8517（2025）09－0041-0

DOI： 10.3969/j . issn.1007-8517. 2025.09. zgmzmjyyzz202509010

Study onthe Mechanism of Dai Medicine“Yajie Shaba”in Treating Staphylococcus Aureus-induced Mastitis inRats

LIWenyan1 LIBenfa² CHEN Wanyil YANG Canru1 HUANG Min *

1.Yunnan UniversityofTraditionalChineseMedicine，Kunming650ooo，China；2.Yunnan HospitalofTraditionalChinese Medicine The First Afiliated Hospital of Yunnan Universityof Traditional Chinese Medicine，Kunming 650oooo，China

Abstract：ObjectiveToexplore the efect and mechanismof dai medicine“Yajie Shaba”on Staphylococcus aureus mastitis in rats.Method SDratswererandomlydivided into5groups：blank control group，aureusrat mastitis modelgroup，and“Yajie Shaba”low，medium and high dose group （ 0.3g/kg ， 0.6g/kg ， 0.9g/kg ），and each group had 3mice.After the molding，theblank controlgroupndthemodelgroupwereinfusedwithnormalsaline，andtherestof thegroupwas giventhecorrespondingdoseof“Yajie Shaba”once a day，the changes of CRP， IL-Iβ ， 1L-6 and IL-8 in serum and the pathological changes of breast tissue in each group were observed.Results There wasnobreast massformation intheblank control group，but breastmass formationintheother groups；thehistopathologicalsectionobservedthatthebreastdamagedegreeinthemodelgroupwassignificantlyhigherthanthatofthe low，medium and high dose group；the content of CRP， 1L-1β ， 1L-6 and 1L-8 in the serum of each group was significantly higher than that of the blank control group.After treatment，the expression of CRP， 1L-1β ， 1L-6 and 1L-8 in serum decreased in the experimental group（The changes in the values in the high- dose group were all P<0.05 ，the expressions of 1L-1β and IL -6 in the middle- dose group were decreased， It was statistically significant， P<0.05 ， and the expression of 1L-6 in the low - dose group wasstatistically significant， P<0.05 ）.Conclusion“Yajie Shaba”can reduce the inflammation of acute mastitis inrats，and its mechanismofactionmayberelatedtotheibitionofproinflammatoryctokines-I-1β，I-6，I-expresionandtasi cal pathway of  N F  - B  signaling pathway.

KeyWords：Yajie Shaba；Staphylococcus Aureus Mastitis；Acute Mastitis；Dai Medicine；Cytokine

急性乳腺炎（acutemastitis，AM）是常见的一种发生于产后哺乳期的乳腺疾病，其临床表现主要为患侧乳腺的红肿、疼痛、肿块，部分患者可伴有发热等全身症状。（剩余6882字）